*EMBARGOED All research presented at the 2018 ACG Annual Scientific Meeting and Postgraduate Course is strictly embargoed until Monday, October 8, 2018, at 8:00 am EDT.
P1614 Roux‐en‐Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy Alter Gut Microbiome in Bariatric Patients
Author Insight from Claire Shin, BS, University of South Carolina School of Medicine Greenville
What’s new here and important for clinicians?
There have been few studies reporting the effects of bariatric surgery on the gut microbiome with variable reporting about the taxonomic changes seen with specific types of bariatric interventions. Our study is a prospective study that compares the fecal microbiome of Roux-en-Y gastric bypass (RYGB), laparoscopic sleeve gastrectomy (LSG) and diet-managed subjects. We report that both RYGB and LSG significantly alter the gut microbiome composition when compared with dietary interventions. There were no significant taxonomic differences between the taxonomic shifts observed between the two surgical interventions. Surgical interventions markedly alter the gut microbiome, and this may potentially inform how individual patients maintain weight loss in the post-operative time period. Additionally, we have identified possible organisms that may contribute to weight loss.
What do patients need to know?
Patients should be aware that post-bariatric surgery weight loss may not be the sole result of mechanical changes of the gut. Further studies to understand the gut microbiome and organisms that contribute will help us to better develop less-invasive and novel therapies for weight loss.
Claire Shin, BS, University of South Carolina School of Medicine Greenville
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